Antonio G García Selected Research

ethyl 5- amino- 6,7,8,9- tetrahydro- 2- methyl- 4- phenylbenzo(1,8)naphthyridine- 3- carboxylate

9/2004

ITH4012 (ethyl 5-amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylate), a novel acetylcholinesterase inhibitor with "calcium promotor" and neuroprotective properties.

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Antonio G García Research Topics

Disease

13	Neuroblastoma 06/2011 - 01/2004
12	Alzheimer Disease (Alzheimer's Disease) 11/2012 - 01/2004
9	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 04/2009
8	Brain Ischemia (Cerebral Ischemia) 01/2017 - 08/2007
6	Hypoxia (Hypoxemia) 03/2015 - 07/2004
5	Neuroinflammatory Diseases 01/2022 - 01/2017
5	Hypertension (High Blood Pressure) 12/2020 - 02/2008
4	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2020 - 11/2011
4	Ischemia 05/2011 - 08/2007
3	Inflammation (Inflammations) 01/2022 - 02/2020
3	Huntington Disease (Huntington's Disease) 03/2020 - 11/2018
3	Stroke (Strokes) 04/2013 - 04/2009
2	Disease Progression 10/2020 - 03/2020
2	Body Weight (Weight, Body) 10/2020 - 05/2005
2	Epilepsy (Aura) 09/2014 - 10/2008
2	Migraine Disorders (Migraine) 09/2014 - 11/2003
2	Reperfusion Injury 02/2009 - 08/2007
1	Status Epilepticus (Complex Partial Status Epilepticus) 01/2022
1	Major Depressive Disorder (Major Depressive Disorders) 11/2021
1	Optic Atrophy 07/2021
1	Hyperalgesia 11/2020
1	Parkinson Disease (Parkinson's Disease) 03/2020
1	Blindness (Hysterical Blindness) 02/2020
1	Retinal Degeneration 02/2020
1	Retinitis Pigmentosa (Pigmentary Retinopathy) 02/2020
1	Sarcoma (Soft Tissue Sarcoma) 01/2020
1	Mitochondrial Diseases (Mitochondrial Disease) 10/2016
1	Spinal Cord Injuries (Spinal Cord Injury) 12/2015

Drug/Important Bio-Agent (IBA)

10	Pharmaceutical PreparationsIBA 01/2022 - 01/2002
8	CalciumIBA 11/2021 - 09/2005
8	Neuroprotective AgentsIBA 10/2011 - 12/2005
8	Galantamine (Galanthamine)FDA LinkGeneric 09/2010 - 01/2004
6	RotenoneIBA 10/2016 - 05/2009
6	CatecholaminesIBA 03/2015 - 11/2008
5	AntioxidantsIBA 01/2020 - 05/2009
5	Glutamic Acid (Glutamate)FDA Link 01/2017 - 01/2006
5	Cholinergic Agents (Cholinergics)IBA 08/2010 - 12/2007
4	Purinergic P2X7 ReceptorsIBA 01/2022 - 01/2020
4	Proteins (Proteins, Gene)FDA Link 07/2021 - 10/2016
4	oligomycin AIBA 01/2011 - 07/2010
3	Free RadicalsIBA 10/2016 - 12/2006
3	LigandsIBA 09/2014 - 05/2009
3	Memantine (Namenda)FDA Link 01/2014 - 07/2004
3	Amyloid beta-PeptidesIBA 11/2012 - 12/2005
3	Tacrine (Cognex)FDA Link 05/2009 - 12/2006
3	Nicotine FDA Link 11/2008 - 12/2005
3	AcetylcholinesteraseIBA 12/2006 - 01/2004
2	Minocycline (Cyclops)FDA LinkGeneric 01/2022 - 01/2014
2	Adenosine Triphosphate (ATP)IBA 01/2022 - 01/2021
2	ResveratrolIBA 12/2020 - 11/2011
2	Oxygen (Dioxygen)IBA 01/2017 - 05/2011
2	ITH14001IBA 01/2017 - 01/2017
2	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 05/2011
2	Nifedipine (Adalat)FDA LinkGeneric 01/2015 - 09/2014
2	Riluzole FDA LinkGeneric 01/2014 - 11/2011
2	Peptides (Polypeptides)IBA 06/2011 - 01/2004
2	Okadaic AcidIBA 06/2011 - 12/2005
2	MelatoninIBA 09/2010 - 05/2009
2	1,4-dihydropyridine (dihydropyridine)IBA 05/2009 - 12/2006
2	salicylhydroxamic acid (SHAM)IBA 02/2009 - 08/2007
2	Cholinesterase Inhibitors (Anticholinesterases)IBA 02/2009 - 12/2005
2	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 12/2005 - 01/2004
1	Midazolam (Versed)FDA LinkGeneric 01/2022
1	ITH15004IBA 01/2022
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2022
1	Carbamazepine (Tegretol)FDA LinkGeneric 01/2022
1	Phenytoin (Dilantin)FDA LinkGeneric 01/2022
1	ConvulsantsIBA 01/2022
1	Kainic Acid (Kainate)IBA 01/2022
1	LipopolysaccharidesIBA 01/2022
1	Lorazepam (Ativan)FDA LinkGeneric 01/2022
1	Ligand-Gated Ion ChannelsIBA 11/2021
1	purineIBA 01/2021
1	Purinergic Receptors (Receptors, Purine)IBA 01/2021
1	NucleotidesIBA 01/2021
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 11/2020
1	Epinephrine (Adrenaline)FDA LinkGeneric 11/2020
1	Phenylethanolamine N-MethyltransferaseIBA 11/2020
1	JNJ-47965567IBA 10/2020
1	SynucleinsIBA 03/2020
1	Neurotransmitter Agents (Neurotransmitter)IBA 03/2020
1	Retinaldehyde (Retinal)IBA 02/2020
1	ITH12674IBA 02/2020
1	DNA (Deoxyribonucleic Acid)IBA 01/2020
1	Superoxide Dismutase-1IBA 01/2020
1	Tetrabenazine (Nitoman)FDA Link 10/2019
1	Dopamine (Intropin)FDA LinkGeneric 10/2019
1	Acetylcholine (Acetylcholine Chloride)FDA Link 11/2018
1	Dihydrotachysterol (AT 10)IBA 01/2017
1	Calbindin 1IBA 10/2016
1	oxophenylarsine (phenylarsine oxide)IBA 10/2016
1	Cytotoxins (Cytolysins)IBA 10/2016
1	OligomycinsIBA 10/2016
1	ParvalbuminsIBA 10/2016
1	VeratridineIBA 10/2016
1	sulfoglycolipidsIBA 12/2015
1	Antihypertensive Agents (Antihypertensives)IBA 10/2015

Therapy/Procedure

5	Therapeutics 01/2022 - 12/2010
1	Drug Therapy (Chemotherapy) 01/2022
1	Denervation 11/2020